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[Experience of using reamberin on the cognitive functions in children with epilepsy]
L A Nosal'1, N V Simonova1, V A Dorovskikh1
1Amur State Medical Academy, Blagoveshchensk, Russia.
Insights
Reamberin, an add-on treatment for childhood epilepsy, significantly improved cognitive functions, including work efficiency and memory. This succinate-containing drug shows promising results for enhancing treatment outcomes in pediatric epilepsy patients.
Area of Science:
- Pediatric Neurology
- Clinical Pharmacology
Background:
- Epilepsy is a common neurological disorder in children.
- Cognitive impairment can be a significant challenge in pediatric epilepsy management.
Purpose of the Study:
- To evaluate the efficacy of reamberin as an adjunctive therapy in children with epilepsy.
- To assess the impact of reamberin on cognitive functions in this patient population.
Main Methods:
- A study involving 51 children (aged 7-15) with epilepsy.
- Patients received either reamberin plus carbamazepine/valproic acid or carbamazepine/valproic acid alone.
- Cognitive functions were assessed using Schulte tables before and after treatment.
Main Results:
- Reamberin addition improved work efficiency by 19-21% and workability by 8-12% compared to controls.
- Auditory memory showed significant improvements: short-term memory increased 1.8-fold and long-term memory 1.3-fold.
- These cognitive enhancements were observed in children receiving reamberin alongside standard antiepileptic drugs.
Conclusions:
- Reamberin demonstrates significant benefits when added to standard epilepsy treatment in children.
- The succinate-containing drug shows promise for improving cognitive deficits associated with pediatric epilepsy.
- Clinical addition of reamberin to epilepsy treatment regimens is considered reasonable and promising.
Objective:
To study the efficacy of reamberin in treatment of epilepsy in children and to evaluate its effect on the cognitive functions.
Material And Methods:
The study included 51 patients with epilepsy aged 7 to 15 years. The children were divided into four groups depending on the prescribed treatment. The first study group (n=16) received intravenous reamberin once daily for 5 days in addition to carbamazepine. The second group (n=15) received intravenous reamberin once daily for 5 days in addition to valproic acid. Two comparison groups (10 patients each) received only carbamazepine or only valproic acid, respectively. Cognitive functions were assessed at admission and on the 6th day of treatment using Schulte tables (10 words).
Results And Conclusion:
Reamberin significantly increases the work efficiency by 19-21%, and workability degree by 8-12% compared with the patients of the control groups. An analysis of the effect of succinate-containing drug on auditory memory has shown that the volumes of short-term memory and long-term memory are by 1.8 times and 1.3 times, respectively, higher than those in the control groups. Thus, the addition of reamberin into the treatment of children with epilepsy should be considered clinically reasonable, and promising.
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