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In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
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Functional non-coding RNAs in vascular diseases.

Koh Ono1, Takahiro Horie1, Osamu Baba1

  • 1Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University, Japan.

The FEBS Journal
|December 19, 2020
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Non-coding RNAs (ncRNAs), including microRNAs and long ncRNAs, play key roles in vascular disease development. This review summarizes their functions and mechanisms in cardiovascular conditions.

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Area of Science:

  • Genomics
  • Molecular Biology
  • Cardiovascular Research

Background:

  • Genomic technologies have identified numerous non-coding RNAs (ncRNAs).
  • MicroRNAs are well-studied in vascular disease, with known disease-causing and protective roles.
  • Other ncRNAs, like long ncRNAs, are emerging as significant factors in vascular disease.

Purpose of the Study:

  • To review the current understanding of ncRNA functions in vascular diseases.
  • To focus on the mechanisms of microRNAs, circular RNAs, and long ncRNAs in cardiovascular conditions.

Main Methods:

  • Literature review of recent studies on ncRNAs and vascular diseases.
  • Synthesis of current knowledge on ncRNA mechanisms and functions.
  • Focus on microRNAs, circular RNAs, and long ncRNAs.

Main Results:

  • ncRNAs, particularly microRNAs, have established roles in vascular disease.
  • Long ncRNAs and circular RNAs are increasingly recognized for their involvement.
  • Understanding these ncRNAs offers insights into disease pathogenesis.

Conclusions:

  • ncRNAs are crucial regulators in the development of vascular diseases.
  • Further research into microRNAs, circular RNAs, and long ncRNAs can reveal therapeutic targets.
  • This review consolidates current knowledge on ncRNAs in cardiovascular health and disease.