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Structural imaging outcomes in subjective cognitive decline: Community vs. clinical-based samples.

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Subjective cognitive decline (SCD) may precede Alzheimer's disease (AD). Brain imaging reveals distinct atrophy patterns in community versus clinic-based SCD samples, impacting diagnosis and research.

Keywords:
AtrophyCommunityMRIMemory clinicSubjective cognitive

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Area of Science:

  • Neuroimaging
  • Neurology
  • Alzheimer's Disease Research

Background:

  • Subjective cognitive decline (SCD) is a potential preclinical stage of Alzheimer's disease (AD).
  • Neuroimaging studies indicate early AD-like brain alterations in SCD individuals.
  • Heterogeneity in findings may stem from community vs. clinic-based sampling.

Purpose of the Study:

  • To review and compare brain atrophy patterns in SCD using structural MRI.
  • To differentiate findings between community-derived and clinic-derived SCD samples.
  • To understand the implications for preclinical AD research.

Main Methods:

  • Systematic review of structural magnetic resonance imaging (sMRI) studies.
  • Analysis of brain atrophy patterns in Subjective Cognitive Decline (SCD) samples.
  • Separate evaluation of community-based and clinic-based SCD cohorts.

Main Results:

  • SCD-community samples consistently show atrophy in the hippocampus, temporal, and parietal cortices.
  • SCD-clinic samples exhibit temporo-parietal vulnerability but display more heterogeneous atrophy patterns.
  • Differences may relate to sample heterogeneity and co-occurring neuropsychiatric symptoms in clinic samples.

Conclusions:

  • Brain atrophy patterns in SCD differ between community and clinic-based samples.
  • The temporal cortex is consistently affected in community samples.
  • Clinic-based samples show complex atrophy, potentially linked to broader symptom profiles in preclinical AD.