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Hollow Microneedle-based Sensor for Multiplexed Transdermal Electrochemical Sensing
Published on: June 1, 2012
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Iontophoresis-driven porous microneedle array patch for active transdermal drug delivery
Yanjun Li1, Jingbo Yang1, Ying Zheng1
1Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument, School of Biomedical Engineering, Sun Yat-sen University, Guangzhou, PR China.
Acta Biomaterialia
|December 19, 2020
Summary
A novel microneedle array (MA) patch combined with iontophoresis (IDPMAP) enables effective, controlled transdermal delivery of macromolecular drugs like insulin for diabetes management.
Area of Science:
- Biomedical Engineering
- Materials Science
- Drug Delivery Systems
Background:
- Transdermal drug delivery faces challenges with macromolecular drugs.
- Combining microneedle arrays (MA) and iontophoresis offers enhanced delivery but requires integration.
- Controllable, self-administered solutions for macromolecular drugs are needed.
Purpose of the Study:
- To develop an integrated microneedle array (MA) patch with iontophoresis for efficient macromolecular drug delivery.
- To create a user-friendly, self-administered system for in situ transdermal treatment.
- To evaluate the efficacy and safety of the developed system for insulin delivery.
Main Methods:
- Development of an iontophoresis-driven porous microneedle array patch (IDPMAP).
- Integration of porous MA and iontophoresis for a one-step drug administration process.
- In vitro and in vivo testing, including transdermal insulin delivery in diabetic rats.
Main Results:
- IDPMAP achieved a 99% skin penetration rate with negligible cytotoxicity and good biocompatibility.
- The system demonstrated effective transdermal delivery of insulin nanovesicles in diabetic rats.
- IDPMAP provided sustained normoglycemia for approximately 5.4 hours, outperforming standalone MA or iontophoresis.
Conclusions:
- IDPMAP offers a user-friendly, efficient, and controllable method for transdermal macromolecular drug delivery.
- The developed system shows significant potential for at-home, self-administered drug treatments, particularly for diabetes.
- This integrated approach overcomes limitations of existing transdermal technologies for complex drug molecules.
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