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Circadian influence on inflammatory response during cardiovascular disease
Iman S Aziz1, Adam M McMahon1, David Friedman1
1Centre for Cardiovascular Investigations, Biomedical Sciences, University of Guelph, 50 Stone Road East, Guelph, Ontario, N1G2W1, Canada.
Current Opinion in Pharmacology
|December 19, 2020
Summary
Circadian rhythms significantly impact cardiovascular health and disease by regulating immune responses. Understanding this connection offers new avenues for diagnosing and treating heart conditions.
Area of Science:
- Cardiovascular Biology
- Immunology
- Chronobiology
Background:
- Circadian rhythms govern 24-hour physiological cycles crucial for cardiovascular health, including repair and remodeling.
- Emerging research highlights the significant impact of circadian rhythms on immune responses within cardiovascular disease contexts.
Purpose of the Study:
- To review the importance of circadian rhythms in cardiovascular health and disease.
- To elucidate the role of the circadian system in modulating inflammation in heart disease, particularly myocardial infarction.
- To explore circadian influences on inflammation in other major cardiovascular conditions.
Main Methods:
- Literature review summarizing current clinical and experimental studies.
- Focus on circadian regulation of key immune cells (neutrophils, monocytes/macrophages, T cells) and inflammasomes (NLRP3).
- Consideration of biological sex differences in circadian immune regulation.
Main Results:
- Circadian rhythms profoundly influence immune responses relevant to cardiovascular disease.
- The circadian system plays a key role in regulating inflammation during cardiac repair, notably after myocardial infarction.
- Circadian regulation of NLRP3 inflammasome, neutrophils, monocytes/macrophages, and T cells is critical for cardiac repair.
Conclusions:
- Circadian regulation of inflammation is integral to cardiovascular health and disease.
- Understanding these circadian influences offers potential for improved diagnosis, treatment, and prognosis in cardiovascular patients.
- Biological sex influences circadian regulation of inflammation in cardiovascular disease.
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