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Peptide-based Identification of Functional Motifs and their Binding Partners

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Published on: June 30, 2013

NF-κB sub-pathways and HIV cure: A revisit.

Lilly M Wong¹, Guochun Jiang²

¹UNC HIV Cure Center, Institute of Global Health and Infectious Diseases, United States.

|December 19, 2020

Summary

This review explores strategies for an HIV cure by targeting Nuclear Factor kappa B (NF-κB) signaling pathways. Understanding NF-κB sub-pathways offers new avenues to disrupt latent HIV reservoirs and achieve a functional cure.

Keywords:

Canonical NF-κB HIV cure HIV latency Noncanonical NF-κB PEBP1 Raf1

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Last Updated: Nov 25, 2025

Peptide-based Identification of Functional Motifs and their Binding Partners

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In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function

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High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

High Throughput In Vitro Assessment of Latency Reversing Agents on HIV Transcription and Splicing

Published on: January 22, 2019

Area of Science:

Virology
Immunology
Molecular Biology

Background:

Human Immunodeficiency Virus (HIV) cure remains elusive due to latent reservoirs.
Antiretroviral Therapy (ART) suppresses but does not eradicate HIV.
Reactivation of latent HIV leads to viral rebound after ART cessation.

Purpose of the Study:

To review curative strategies for HIV focusing on NF-κB signaling pathways.
To explore the role of canonical and noncanonical NF-κB signaling in HIV latency reversal.
To identify novel upstream signaling pathways of NF-κB for HIV functional cure.

Main Methods:

Literature review of existing research on HIV cure strategies.
Analysis of NF-κB signaling pathways and their impact on HIV latency.
Exploration of upstream regulators of NF-κB in the context of HIV.

Main Results:

Canonical NF-κB signaling is known to induce HIV proviral expression.
Noncanonical NF-κB signaling also promotes HIV expression from latency.
Novel upstream signaling pathways of NF-κB present new therapeutic targets.

Conclusions:

Targeting NF-κB sub-pathways shows promise for disrupting latent HIV.
Both canonical and noncanonical NF-κB pathways are implicated in HIV latency reversal.
Investigating upstream NF-κB signaling may lead to a functional HIV cure.