Elevated sCD14 in cerebrospinal fluid: a surrogate marker for HIV-associated neurocognitive disorders in Brazil
Carlos F Apoliano1, Ana C S de Oliveira2, Víctor  Folgosi1
1Laboratório de Investigação Médica LIM-56 - Divisão de Dermatologia, Faculdade de Medicina da Universidade de São Paulo.
AIDS (London, England)
|December 29, 2025
Abstract:
This study investigates cerebrospinal fluid (CSF) biomarkers associated with HIV-associated neurocognitive disorders (HAND) in people with HIV (PWH) in Brazil. Among 79 HIV-positive participants and 7 negative controls, elevated levels of inflammatory cytokines and soluble CD14 (sCD14) were found. The sCD14 showed promise as a diagnostic marker, and combined with other proinflammatory markers, may improve early detection and monitoring of HAND.


