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Related Concept Videos

Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

300
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
300
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

464
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
464
Dialysis01:27

Dialysis

896
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
896
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

567
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
567
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

134
Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
134
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

264
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
264

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Related Experiment Video

Updated: Nov 25, 2025

Standardized Colon Ascendens Stent Peritonitis in Rats - a Simple, Feasible Animal Model to Induce Septic Acute Kidney Injury
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[Acute renal failure in COVID-19].

A Gäckler1, H Rohn2, O Witzke2

  • 1Klink für Nephrologie, Universitätsmedizin Essen, Universität Duisburg-Essen, Hufelandstr. 55, 45147 Essen, Deutschland.

Der Nephrologe
|December 21, 2020
PubMed
Summary
This summary is machine-generated.

Acute kidney injury (AKI), a frequent complication of coronavirus disease 2019 (COVID-19), may lead to persistent kidney function loss. Renal function re-evaluation post-COVID-19 recovery is recommended.

Keywords:
ComplicationsCoronavirusExtracorporeal blood purificationPathophysiologyRenal insufficiency

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Area of Science:

  • Nephrology
  • Virology
  • Critical Care Medicine

Context:

  • Acute kidney injury (AKI) is a common complication in patients with coronavirus disease 2019 (COVID-19).
  • AKI in COVID-19 is associated with respiratory failure, increased morbidity, and mortality.
  • The exact causes of AKI in COVID-19 are multifactorial, potentially including direct viral kidney involvement.

Purpose:

  • To review the current understanding of AKI in COVID-19.
  • To highlight the lack of specific treatments for COVID-19-associated AKI.
  • To emphasize the need for renal function assessment after COVID-19 recovery.

Summary:

  • COVID-19-associated AKI is frequent and linked to poor outcomes.
  • Direct viral kidney damage is a suspected cause of AKI in COVID-19.
  • Current treatment options for COVID-19 AKI are limited, and the role of extracorporeal procedures remains unclear.
  • Emerging data suggest persistent renal function decline after COVID-19-associated AKI.

Impact:

  • Highlights the significant renal impact of COVID-19.
  • Underscores the need for further research into COVID-19-associated AKI pathogenesis and treatment.
  • Recommends routine renal function monitoring in COVID-19 survivors to detect long-term kidney damage.