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Related Concept Videos

Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

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Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
415
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

184
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
184
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

414
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
414
Acute Kidney Injury II: Pathophysiology01:29

Acute Kidney Injury II: Pathophysiology

650
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
650
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

579
Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
579
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

364
Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
364

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[COVID-19 and the kidneys].

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Related Experiment Video

Updated: Dec 11, 2025

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice

Published on: May 2, 2025

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[COVID-19 and the kidneys].

H Rohn1, T Feldkamp2, O Witzke1

  • 1Klinik für Infektiologie, Westdeutsches Zentrum für Infektiologie (WZI), Universitätsmedizin Essen, Universität Duisburg-Essen, Hufelandstr. 55, 45147 Essen, Deutschland.

Der Nephrologe
|August 25, 2020
PubMed
Summary
This summary is machine-generated.

Emerging infectious diseases like COVID-19 have severe societal impacts. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a significant focus of current scientific and public attention.

Keywords:
Acute kidney injuryCOVID-19Chronic renal insufficiencyPandemicsSARS-Coronavirus‑2

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Area of Science:

  • Epidemiology
  • Public Health

Context:

  • The global emergence of novel pathogens presents significant challenges to public health systems worldwide.
  • Coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, exemplifies the profound societal and individual consequences of emerging infectious diseases.

Purpose:

  • To highlight the critical need for understanding and preparedness regarding emerging infectious diseases.
  • To underscore the scientific and public interest surrounding SARS-CoV-2 and its impact.

Summary:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in late 2019, rapidly becoming a global health concern.
  • The ongoing COVID-19 pandemic demonstrates the drastic consequences of emerging infectious diseases on individuals and societies.

Impact:

  • Increased focus on infectious disease surveillance and response mechanisms.
  • Accelerated research into viral pathogenesis, transmission, and therapeutic interventions for SARS-CoV-2.