Related Experiment Video
Updated: Oct 22, 2025
08:21
A Modified Two Kidney One Clip Mouse Model of Renin Regulation in Renal Artery Stenosis
Published on: October 26, 2020
5.1K
[Inhibition of the renin-angiotensin-aldosterone system]
1Klinik für Nieren- und Hochdruckerkrankungen, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Deutschland.
Der Nephrologe
|August 30, 2021
Summary
Chronic kidney disease (CKD) progression can be slowed by targeting the renin-angiotensin-aldosterone system (RAAS). Novel treatments, like mineralocorticoid receptor antagonists, show promise for improved kidney function.
Area of Science:
- Nephrology
- Pharmacology
- Endocrinology
Context:
- Chronic kidney diseases (CKD) represent a progressive decline in renal function, offering a window for therapeutic intervention.
- The renin-angiotensin-aldosterone system (RAAS) is a critical factor in the progression of kidney damage.
- Identifying effective therapeutic targets is essential for managing CKD.
Purpose:
- To review the mechanisms of RAAS-mediated kidney damage.
- To explore pharmaceutical strategies for inhibiting the RAAS.
- To summarize clinical evidence for nephroprotection and discuss guideline recommendations.
Summary:
- This review details how RAAS activation contributes to renal dysfunction.
- It examines current drug therapies targeting the RAAS for kidney protection.
- The FIDELIO-DKD study's findings on nonsteroidal mineralocorticoid receptor antagonists as an add-on therapy are discussed.
Impact:
- Provides a comprehensive overview of RAAS in CKD pathogenesis and treatment.
- Highlights the role of RAAS inhibition in nephroprotection.
- Discusses emerging therapeutic strategies, including mineralocorticoid receptor antagonists, for future CKD management.
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