Related Experiment Video

Updated: Nov 25, 2025

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
05:34

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats

Published on: April 4, 2025

1.2K

Outcomes of COVID-19 Among Hospitalized Patients With Non-dialysis CKD

Armando Coca1,2, Carla Burballa2,3, Francisco Javier Centellas-Pérez2,4

  • 1Department of Nephrology, Hospital Clínico Universitario Valladolid, Valladolid, Spain.

Frontiers in Medicine
|December 21, 2020
PubMed

Insights

Patients with chronic kidney disease (CKD) hospitalized for COVID-19 face significantly higher risks of death and acute kidney injury (AKI). This highlights the vulnerability of CKD patients during the COVID-19 pandemic.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Coronavirus disease 2019 (COVID-19) poses a global health threat, potentially causing pneumonia and organ damage.
  • While prior epidemics suggest increased mortality for chronic kidney disease (CKD) patients, specific risks for non-dialysis CKD individuals with COVID-19 remain understudied.

Purpose of the Study:

  • To evaluate the risks of mortality and acute kidney injury (AKI) in non-dialysis CKD patients hospitalized with COVID-19 compared to matched controls.

Main Methods:

  • A multicenter, observational cohort study included 136 non-dialysis CKD patients and 136 age/sex-matched controls hospitalized for COVID-19.
  • Exclusion criteria included end-stage renal disease, kidney transplant, or lack of baseline glomerular filtration rate.
  • CKD and AKI were defined using KDIGO criteria.

Main Results:

  • CKD patients exhibited higher white blood cell counts and D-dimer levels, and lower lymphocyte percentages.
  • CKD was associated with substantially higher rates of AKI (61% vs. 24.3%) and mortality (40.4% vs. 24.3%).
  • Patients with AKI had the highest hazard for death, followed by CKD patients without AKI.

Conclusions:

  • Hospitalization for COVID-19 significantly increases the risk of mortality and AKI in non-dialysis CKD patients.
  • CKD status did not influence ICU admission or length of hospital stay.

Keywords:
COVID−19acute kidney damagechornic kidney diseasepneumoniarenal failure

More Related Videos

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

4.7K
A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice06:27

A Retrograde Implantation Approach for Peritoneal Dialysis Catheter Placement in Mice

Published on: July 20, 2022

2.9K

Related Concept Videos

Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
208
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
361
Acute Kidney Injury III: Clinical Manifestations01:29

Acute Kidney Injury III: Clinical Manifestations

Acute Kidney Injury (AKI) progresses through distinct clinical phases: the oliguric, diuretic, and recovery phases, each marked by unique manifestations and challenges.Oliguric Phase:The oliguric phase is the initial stage of AKI, typically lasting 10 to 14 days. This phase is marked by a significant reduction in urine output, usually less than 400 mL per day, indicating decreased kidney function. Fluid retention is a prominent feature, leading to symptoms such as edema, hypertension, and...
464
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
145
Acute Kidney Injury V: Interprofessional Care01:20

Acute Kidney Injury V: Interprofessional Care

Acute Kidney Injury (AKI) requires a collaborative healthcare approach to restore renal function and prevent complications. Essential management strategies involve monitoring fluid and electrolyte balance, adjusting medications, initiating dialysis when necessary, and providing nutritional support.Fluid and Electrolyte ManagementFluid Monitoring: Regularly monitoring body weight, central venous pressure, and urine output helps detect fluid imbalances early. Patient intake and output are...
134
Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
361