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The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
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Erratum to "Colony stimulating factor-1 receptor drives glomerular parietal epithelial cell activation in focal segmental glomerulosclerosis." Kidney International 2024;106:67-84.

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Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol
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Living Kidney Donation: An Update.

Ana González Rinne1, Anna Manonelles2, Carla Burballa3

  • 1Department of Nephrology, Hospital Universitario de Canarias, Tenerife, Spain, anamaria.gonzalez.rinne@gmail.com.

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|March 3, 2026
PubMed
Summary
This summary is machine-generated.

Ensuring living donor kidney donor safety is crucial. This review details evaluating complex donor profiles, using precise tools like mGFR, and the importance of long-term follow-up for safe expansion of living kidney donation.

Keywords:
Borderline donorKidney transplantLiving donorRisk evaluation

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Area of Science:

  • Nephrology
  • Transplant Surgery
  • Medical Ethics

Background:

  • Living donor kidney transplantation (LDKT) provides better long-term results than deceased donor transplantation.
  • Prioritizing donor safety is paramount in the clinical assessment for LDKT.
  • Evaluating pre-donation risks is complex, especially in borderline cases with limited evidence.

Purpose of the Study:

  • To review critical aspects of decision-making in living kidney donor (LKD) assessment.
  • To address the evaluation of potential donors with complex medical or psychosocial profiles.
  • To highlight the importance of precise evaluation tools and long-term follow-up for donor safety.

Main Methods:

  • Literature review of current practices and evidence in LKD assessment.
  • Exploration of risk stratification tools and their application in borderline cases.
  • Discussion of emerging technologies like genetic testing and their role in donor evaluation.

Main Results:

  • Evaluation strategies for donors with obesity, advanced age, psychiatric history, or substance use are discussed.
  • The significance of measured glomerular filtration rate (mGFR) for borderline kidney function is emphasized.
  • Socioeconomic, cultural, and religious factors influencing donation willingness and selection are considered.

Conclusions:

  • Precise evaluation tools, robust long-term follow-up, and ongoing research are vital for safely expanding the living kidney donor pool.
  • Accurate risk stratification and improved decision-making guidelines are needed.
  • This review identifies current knowledge and practice gaps in LKD evaluation.