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Bromodomain-containing protein 4 and its role in cardiovascular diseases

Liang Li1,2, Wei Xie2,3, Yu Gui2

  • 1Department of Pathophysiology, Institute of Cardiovascular Research, Key Laboratory for Atherosclerology of Hunan Province, Medical Research Center, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hengyang, Hunan, China.

Journal of Cellular Physiology
|December 21, 2020
PubMed

Insights

Bromodomain-containing protein 4 (BRD4) is implicated in cardiovascular diseases like heart disease and hypertension. Targeting BRD4 may offer new therapeutic strategies for treating these conditions.

Area of Science:

  • Cardiovascular Biology
  • Molecular Biology
  • Oncology

Background:

  • Bromodomain-containing protein 4 (BRD4) is a chromatin-binding protein known for its role in tumor development.
  • Emerging evidence highlights BRD4's involvement in cardiovascular pathophysiology.
  • BRD4 influences key cellular processes relevant to cardiovascular health.

Purpose of the Study:

  • To review the multifaceted roles of BRD4 in cardiovascular diseases.
  • To explore BRD4's regulatory functions in pathophysiological processes of the cardiovascular system.
  • To assess BRD4 as a potential therapeutic target for cardiovascular conditions.

Main Methods:

  • Literature review of studies investigating BRD4 in cardiovascular contexts.
  • Analysis of existing research on BRD4's molecular mechanisms in cardiovascular diseases.
  • Synthesis of evidence linking BRD4 to ischemic heart disease, hypertension, and cardiac hypertrophy.

Main Results:

  • BRD4 is identified as a key regulator in various cardiovascular disease pathways.
  • Evidence supports BRD4's role in the pathogenesis of ischemic heart disease.
  • BRD4 involvement is noted in hypertension and cardiac hypertrophy development.

Conclusions:

  • BRD4 plays a significant role in the development and progression of cardiovascular diseases.
  • BRD4 emerges as a promising novel therapeutic target for cardiovascular diseases.
  • Further research into BRD4 modulation could lead to new treatment strategies for heart conditions.

Keywords:
BRD4cardiac hypertrophycardiovascular diseaseshypertensionischemic heart disease

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