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Current innovations in drug delivery.

D Ganderton1

  • 1Chelsea Department of Pharmacy, King's College London, UK.

Drug Design and Delivery
|September 1, 1987
PubMed
Summary

Pharmaceutical companies are improving drug delivery systems to control medication release. Advances focus on controlled absorption rates and extended drug action for better therapeutic outcomes.

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Area of Science:

  • Pharmaceutical Technology
  • Drug Delivery Systems
  • Pharmacokinetics

Background:

  • The pharmaceutical industry has focused on improving existing medicines for nearly two decades.
  • Progress has been made in controlling drug release duration and intensity, with site specificity as a future goal.

Purpose of the Study:

  • To review advancements in drug delivery systems that modulate drug release.
  • To explore various routes of administration and their impact on drug absorption and therapeutic efficacy.

Main Methods:

  • Review of passive dosage forms for controlled systemic absorption.
  • Exploration of oral, rectal, percutaneous, and parenteral administration routes.
  • Analysis of strategies for variable/pulsed release and extended transit time.

Main Results:

  • Oral administration has dominated drug delivery innovation.
  • Successful marketing of products utilizing controlled absorption rates.
  • Percutaneous drug delivery shows commercial success, with ongoing refinement.

Conclusions:

  • Advanced drug delivery systems aim for demand-based release (e.g., glucose levels).
  • Future developments include variable release, extended transit times, and improved drug loading.
  • Penetration enhancers are key for expanding percutaneous drug delivery.

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