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Updated: Nov 24, 2025
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A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
Published on: June 24, 2020
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Severe adverse maternal outcomes associated with chorioamnionitis.
Allison K Perry1, Robert M Rossi1, Emily A DeFranco1
1Department of Obstetrics and Gynecology, University of Cincinnati College of Medicine, Cincinnati, OH.
American Journal of Obstetrics & Gynecology MFM
|December 21, 2020
Summary
Chorioamnionitis significantly increases severe maternal risks, including intensive care unit admission and other adverse outcomes. This highlights the need for better prevention and treatment strategies to reduce maternal morbidity.
Area of Science:
- Obstetrics and Gynecology
- Maternal-Fetal Medicine
- Public Health
Background:
- Chorioamnionitis affects 1-5% of pregnancies, posing risks to newborns.
- Prolonged labor and induction may increase chorioamnionitis rates.
Purpose of the Study:
- To quantify serious adverse maternal outcomes linked to chorioamnionitis.
- Focus on a contemporary population of live births in Ohio.
Main Methods:
- Population-based retrospective cohort study of Ohio live births (2006-2015).
- Compared maternal outcomes between women with and without chorioamnionitis using birth certificate data.
- Multivariate logistic regression analyzed associations with adverse maternal outcomes.
Main Results:
- 1.3% of births (17,430) had chorioamnionitis.
- Chorioamnionitis associated with higher rates of ICU admission (0.5% vs 0.1%) and composite adverse outcomes (5.0% vs 1.5%).
- Adjusted analysis showed a 2- to 3-fold increased risk for adverse outcomes, including ICU admission, blood transfusion, and uterine rupture.
Conclusions:
- Chorioamnionitis leads to frequent severe adverse maternal outcomes, affecting 1 in 20 cases.
- Increased risk for maternal intensive care unit admission is nearly 3-fold.
- Preventing and treating chorioamnionitis is crucial for reducing severe maternal morbidity in the US.
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