Regulated Necrotic Cell Death in Alternative Tumor Therapeutic Strategies
Yunseo Woo1,2, Hyo-Ji Lee1,2, Young Mee Jung2,3
1Department of Biological Sciences, Kangwon National University, Chuncheon 24341, Korea.
Cells
|December 22, 2020
Summary
Targeting cancer requires inducing cell death. This review explores regulated necrotic cell death (RNCD) mechanisms like necroptosis, pyroptosis, and ferroptosis as novel anticancer strategies for resistant tumors.
Area of Science:
- Oncology
- Cell Biology
- Molecular Medicine
Background:
- Cancer treatment relies on inducing cancer cell death.
- Conventional therapies (radiotherapy, chemotherapy, immunotherapy) face challenges due to cancer cell resistance.
- Regulated cell death (RCD) offers diverse mechanisms for controlled cell elimination.
Purpose of the Study:
- To review the mechanisms of necroptosis, pyroptosis, and ferroptosis.
- To explore the potential of regulated necrotic cell death (RNCD) in cancer therapy.
- To suggest RNCD induction as a strategy against apoptosis- or autophagy-resistant tumors.
Main Methods:
- Literature review of RCD mechanisms.
- Detailed analysis of necroptosis, pyroptosis, and ferroptosis pathways.
- Exploration of RNCD's role in tumor inflammation and therapeutic potential.
Main Results:
- Necroptosis, pyroptosis, and ferroptosis are distinct forms of RCD.
- These RNCDs involve plasma membrane disruption and specific protein regulation.
- RNCDs induce inflammation, offering a therapeutic avenue.
Conclusions:
- RNCDs represent promising therapeutic strategies for cancer treatment.
- Targeting RNCD can overcome resistance to apoptosis and autophagy.
- Further research into RNCD mechanisms can enhance anticancer efficacy.
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