Parry-Romberg syndrome: a mini review.

Area of Science:

• Dermatology
• Neurology
• Genetics

Background:

• Parry-Romberg syndrome (PRS) is a rare disorder characterized by progressive atrophy of facial soft and hard tissues.
• It typically manifests in the first two decades of life and is more prevalent in females.
• The etiology of PRS remains uncertain, and its slow progression can lead to significant cosmetic and psychological challenges.

Purpose of the Study:

• To provide a detailed description of Parry-Romberg syndrome (PRS).
• To compare PRS with its close differential diagnosis, linear morphea en coup de sabre (ECDS).
• To highlight PRS as a potential part of a broader disease spectrum that includes ECDS.

Main Methods:

• Literature review of Parry-Romberg syndrome (PRS) and linear morphea en coup de sabre (ECDS).
• Comparative analysis of clinical features, progression, and management of PRS and ECDS.
• Discussion of the shared disease spectrum between PRS and ECDS.

Main Results:

• PRS involves progressive, slow atrophy of facial tissues, with severity correlating with age of onset.
• Neurological and ophthalmological involvement are common complications of PRS.
• ECDS is presented as a potentially milder variant within the same disease spectrum as PRS.

Conclusions:

• Parry-Romberg syndrome (PRS) is a distinct but related entity to ECDS, suggesting a shared underlying pathology.
• Management of PRS is primarily cosmetic and undertaken after disease stabilization.
• Further research into the etiology and spectrum of these related conditions is warranted.