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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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[French ccAFU guidelines - update 2020-2022: retroperitoneal sarcoma].

T Murez1, P-H Savoie2, A Fléchon3

  • 1Comité de cancérologie de l'Association française d'urologie, groupe organes génitaux externes, Maison de l'urologie, 11, rue Viète, 75017 Paris, France; Service d'urologie et de transplantation rénale, CHU de Montpellier, 371, avenue du Doyen-Gaston-Giraud, 34295 Montpellier, Cedex 5, France.

Progres En Urologie : Journal De L'Association Francaise D'Urologie Et De La Societe Francaise D'Urologie
|December 22, 2020
PubMed
Summary
This summary is machine-generated.

French urological guidelines for retroperitoneal sarcoma emphasize prompt diagnosis and treatment. High-volume centers and specialized networks are crucial for improving patient outcomes in managing this rare cancer.

Keywords:
ChirurgieDiagnosisDiagnosticPrognosisPronosticRadiotherapyRadiothérapieRetroperitonealRétropéritoineSarcomaSarcomeSurgery

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Area of Science:

  • Urological Oncology
  • Surgical Pathology
  • Medical Imaging

Background:

  • Retroperitoneal sarcoma is a rare and aggressive malignancy.
  • Optimal management strategies require updated clinical guidelines.

Purpose of the Study:

  • To provide updated French urological guidelines for retroperitoneal sarcoma.
  • To define best practices for diagnosis, treatment, and follow-up.

Main Methods:

  • A comprehensive literature search of Medline (2018-2020) was conducted.
  • Evidence levels were evaluated for diagnosis, treatment, and follow-up protocols.
  • Guidelines were updated based on current scientific evidence.

Main Results:

  • Mandatory CT scans (chest, abdomen, pelvis) for suspected retroperitoneal sarcoma; MRI aids surgical planning.
  • Biopsy and registration in a French sarcoma network are required before treatment decisions.
  • Surgery is the cornerstone, aiming for negative margins; multidisciplinary team discussion is essential.
  • Relapse rates correlate with tumor grade and surgical margins, favoring high-volume centers.

Conclusions:

  • Prognosis for retroperitoneal sarcoma is poor, heavily influenced by initial management quality.
  • Centralization of care within dedicated sarcoma networks and high-volume centers is imperative.