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Could serum albumin value and thrombocyte/lymphocyte ratio be an important prognostic factor in determining the

Emel Uyar1, Alparslan Merdin2, Serdar Yamanyar1

  • 1Department of Critical Care Medicine, University of Health Sciences, Gülhane Education Research Hospital, Ankara, Turkey

Turkish Journal of Medical Sciences
|December 22, 2020
PubMed

Insights

Serum albumin and thrombocyte/lymphocyte ratio (TLO-2) can predict COVID-19 severity. Lower albumin and higher TLO-2 indicate a greater need for intensive care, aiding in clinical risk assessment for COVID-19 patients.

Area of Science:

  • Clinical Medicine
  • Hematology
  • Infectious Diseases

Background:

  • COVID-19 severity prediction is crucial for patient management.
  • Identifying reliable clinical markers for risk assessment is an ongoing area of research.

Purpose of the Study:

  • To investigate the association between serum albumin levels and thrombocyte/lymphocyte ratio (TLO) with COVID-19 disease severity.
  • To evaluate the potential of these markers in predicting the need for intensive care unit (ICU) admission.

Main Methods:

  • Patients were stratified into groups based on disease severity.
  • Demographic data, serum albumin, lymphocyte count, and thrombocyte/lymphocyte ratios (TLO-1 and TLO-2) were recorded.
  • Statistical analysis was performed to compare markers between severity groups.

Main Results:

  • Significant differences were observed in age, comorbidity, lymphocyte counts, TLO ratios, and serum albumin levels between severity groups.
  • Patients with severe COVID-19 (ICU group) were older, had more comorbidities, lower lymphocyte counts, higher TLO ratios (TLO-1 and TLO-2), and lower serum albumin levels.
  • No significant differences were found in sex or thrombocyte counts at admission or during hospitalization.

Conclusions:

  • The thrombocyte/lymphocyte ratio (TLO-2) and lymphocyte count are significant indicators of COVID-19 severity.
  • A TLO-2 ratio above 260 and a lymphocyte count below 1,103 cells/μL may predict the need for intensive care.
  • Serum albumin levels are also associated with disease severity, with lower levels indicating poorer outcomes.
Abstract

Keywords:
Severity of COVID 19platelet lenfosit ratioserum albumin value

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