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Manipulation and Analysis of Cell Cycle-Dependent Processes in Budding Yeast
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Cellular quiescence in budding yeast.

Siyu Sun1,2, David Gresham1,2

  • 1Center for Genomics and Systems Biology, New York University, New York, New York, 10003, USA.

Yeast (Chichester, England)
|December 22, 2020
PubMed
Summary
This summary is machine-generated.

Cellular quiescence is a reversible cell cycle exit, crucial for understanding cell life cycles and diseases like cancer. Research in budding yeast provides insights into this fundamental biological state across eukaryotes.

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Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • Cellular quiescence, a reversible exit from cell proliferation, is the predominant state for all cells.
  • Understanding the molecular mechanisms of quiescence is incomplete, despite its prevalence.
  • Budding and fission yeast serve as key model systems due to conserved pathways and experimental tractability.

Purpose of the Study:

  • To review current knowledge of cell quiescence in budding yeast.
  • To connect findings in yeast to quiescence in other eukaryotes, including animals.
  • To highlight unresolved questions and propose advancements in the field.

Main Methods:

  • Review of existing literature on cell quiescence in yeast.
  • Analysis of conserved pathways and processes across eukaryotes.
  • Summary of methods used for studying quiescence in yeast.

Main Results:

  • Quiescence involves dynamic, large-scale remodeling of cellular processes, organelles, gene expression, and metabolism.
  • Three distinct phases of quiescence are identified: initiation, maintenance, and exit.
  • Quiescence impacts microbial survival and human diseases like cancer.

Conclusions:

  • Standardized criteria and methods are needed to accelerate research on cell quiescence.
  • Integrated approaches and single-cell analyses are essential for a complete understanding.
  • Studying quiescence in yeast offers broad implications for fundamental biology and human health.