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Multicystic Dysplastic Kidney: Prenatal Compensatory Renal Growth Pattern
Noa Gilad1,2, Alina Weissmann-Brenner1,2, Yinon Gilboa1,2
1Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Summary
The normal kidney opposite a multicystic dysplastic kidney (MCDK) shows unique prenatal growth, accelerating in the third trimester. This contrasts with solitary kidneys and informs parental counseling on renal outcomes.
Area of Science:
- Fetal medicine
- Pediatric nephrology
- Urology
Background:
- Multicystic dysplastic kidney (MCDK) is a common congenital anomaly.
- Understanding the growth of the contralateral normal kidney is crucial for prenatal assessment and counseling.
Purpose of the Study:
- To characterize the prenatal growth pattern of the normal kidney contralateral to a unilateral MCDK.
- To compare this growth pattern with that of a solitary kidney.
Main Methods:
- Retrospective analysis of 47 isolated fetal MCDK cases over 4 years.
- Creation of nomograms for the contralateral normal kidney's growth.
- Statistical comparison with growth patterns of solitary kidneys.
Main Results:
- The contralateral normal kidney exhibits linear growth throughout gestation.
- Significant growth acceleration was observed in the third trimester (29-38 weeks).
- This kidney showed a higher compensatory growth trend in the third trimester compared to solitary kidneys.
Conclusions:
- The contralateral normal kidney has a distinct intrauterine growth trajectory, with third-trimester acceleration.
- The mechanism behind this pattern, versus early hypertrophy in solitary kidneys, requires further investigation.
- These findings aid in prenatal counseling regarding renal outcomes.
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