Does enteral zinc supplementation improve growth and clinical outcome in preterm babies <37 weeks?

To review the literature of the benefits of enteral zinc supplementation in preterm population <37 weeks to improve growth and clinical outcome.

PubMed database was searched for relevant articles. Studies not in English were excluded.

A total of 2678 results were identified. Duplicates were removed and titles were screened. References were reviewed to find other papers. Studies which include term infants were not examined although studies involving low birthweight infants with a defined percentage of preterm participants were examined. Thirty-four studies were subsequently reviewed, and nine studies were included as relevant to structured clinical question.

There are various levels of evidence suggesting benefits of enteral zinc supplementation in preterm babies. While the available trial findings are encouraging, there is currently limited evidence to address the effects of zinc supplementation in preterm infants in the setting of their typically long stay in Neonatal Intensive Care Unit. A larger multi-centre trial is required to establish optimal timing of initiation, dosage, duration and its effect on growth, development and acute morbidity and mortality.