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Is Willebrand Factor Indicative of Chronic Inflammation in Children with Asthma?

Nataliia Makieieva1, Valeriia Malakhova1, Yuliia Vasylchenko1

  • 1Department of Pediatrics, Kharkiv National Medical University, Kharkiv, Ukraine.

Turkish Thoracic Journal
|December 22, 2020
PubMed

Insights

Elevated von Willebrand factor levels in children with recurrent wheezing indicate endothelial dysfunction. Persistent high levels suggest chronic inflammation, potentially signifying the development of asthma.

Area of Science:

  • Pediatric Pulmonology
  • Vascular Biology
  • Inflammation Research

Background:

  • Recurrent wheezing and asthma are common in children.
  • Understanding the underlying inflammatory processes is crucial for effective management.
  • Endothelial dysfunction may play a role in the pathogenesis of childhood asthma.

Purpose of the Study:

  • To investigate the association between von Willebrand factor (vWF) levels and chronic inflammation in children with recurrent wheezing and asthma.
  • To determine if vWF levels can serve as an indicator for the development of asthma.
  • To explore the relationship between vWF levels and the severity of wheezing episodes.

Main Methods:

  • Prospective cohort study involving children with recurrent wheezing and asthma.
  • Patients were categorized into three groups based on the number of wheezing episodes.
  • von Willebrand factor levels were measured at admission and post-treatment.

Main Results:

  • von Willebrand factor (vWF) levels were significantly elevated in children with more frequent wheezing episodes compared to controls.
  • vWF levels remained high in the most severely affected group even after treatment.
  • vWF levels decreased to normal ranges in children with fewer wheezing episodes after treatment.

Conclusions:

  • Elevated vWF levels are indicative of endothelial dysfunction in children with recurrent wheezing.
  • The magnitude of vWF elevation correlates with the number of wheezing episodes.
  • Sustained high vWF levels, despite symptom relief, suggest ongoing chronic inflammation and potential asthma development.
Abstract

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