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Natural and Synthetic PPARγ Ligands in Tumor Microenvironment: A New Potential Strategy against Breast Cancer

Giuseppina Augimeri1,2, Luca Gelsomino1, Pierluigi Plastina1

  • 1Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende (CS), Italy.

International Journal of Molecular Sciences
|December 23, 2020
PubMed

Insights

Activation of peroxisome proliferator-activated receptor γ (PPARγ) shows tumor-suppressive effects in breast cancer. PPARγ ligands may be effective agents against breast cancer by targeting both cancer cells and the tumor microenvironment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Breast cancer is a complex disease involving neoplastic epithelial cells and the tumor microenvironment (TME).
  • The TME plays a critical role in breast cancer development and progression.
  • Peroxisome proliferator-activated receptor γ (PPARγ) activation demonstrates tumor-suppressive effects in various cancers, including breast carcinoma.

Purpose of the Study:

  • To review the activity of PPARγ within the breast tumor microenvironment.
  • To focus on PPARγ's role in both epithelial and stromal cells, as well as extracellular matrix components.

Main Methods:

  • In vitro studies.
  • In vivo research.

Main Results:

  • PPARγ activation influences both epithelial and stromal cells within the breast TME.
  • PPARγ affects extracellular matrix components relevant to breast cancer progression.
  • Evidence suggests PPARγ ligands have therapeutic potential.

Conclusions:

  • PPARγ ligands represent promising agents for combating breast cancer.
  • Targeting PPARγ offers a potential strategy for novel breast cancer therapies by modulating the TME.
Keywords:
PPARγ ligandsbreast cancercancer-associated adipocytescancer-associated fibroblastsextracellular matrix componentsextracellular vesiclesperoxisome proliferator-activated receptor gammatumor endothelial cellstumor microenvironmenttumor-associated macrophages

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