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Chitosan and Cellulose-Based Hydrogels for Wound Management.

Sibusiso Alven1, Blessing Atim Aderibigbe1

  • 1Department of Chemistry, University of Fort Hare, Alice Campus, Eastern Cape 5700, South Africa.

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Summary

This review explores advanced wound dressings, focusing on hydrogels derived from chitosan and cellulose. These biopolymer-based hydrogels offer enhanced properties for effective wound healing and infection prevention.

Keywords:
acute woundsburn woundscellulosechitosanchronic woundsdiabetic woundshydrogelwound dressings

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Polymer Chemistry

Background:

  • Effective wound management is crucial for acute and chronic wounds.
  • Current wound dressings include hydrogels, films, foams, and bandages.
  • Hydrogels offer a moist environment, bacterial barrier, and are suitable for exuding wounds.

Purpose of the Study:

  • To review hydrogels formulated from chitosan and cellulose for improved wound management.
  • To highlight the benefits of biopolymer-based hydrogels in wound healing.
  • To discuss the potential of these hydrogels in accelerating skin regeneration.

Main Methods:

  • Review of literature on hydrogels derived from chitosan and cellulose.
  • Analysis of biopolymer properties (non-toxic, biodegradable, biocompatible).
  • Investigation of crosslinking techniques with synthetic polymers to enhance hydrogel properties.

Main Results:

  • Chitosan and cellulose hydrogels demonstrate improved mechanical, biological, and physicochemical properties.
  • These hydrogels accelerate wound re-epithelialization and mimic skin structure.
  • Incorporation of antibacterial agents into hydrogels prevents wound infections.

Conclusions:

  • Chitosan-cellulose hydrogels represent promising advanced wound dressing materials.
  • Their properties support skin regeneration and infection control.
  • Further development can enhance therapeutic outcomes in wound management.