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Therapeutic options for resectable second lung tumor after previous pneumonectomy: a SEER database analysis
Xiangyang Yu1, Shugeng Gao1, Qi Xue1
1Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
For patients with a second lung tumor after pneumonectomy, sublobar resection or non-surgical options offer reasonable long-term survival with acceptable mortality. These treatments are viable for resectable postpneumonectomy second lung tumors.
Area of Science:
- Thoracic Surgery
- Oncology
- Pulmonary Medicine
Background:
- Treatment options for second lung tumors (SLT) after pneumonectomy are limited and debated.
- This study evaluates outcomes of different treatment strategies for resectable postpneumonectomy SLT.
Purpose of the Study:
- To compare short- and long-term outcomes of various treatment patterns in patients with resectable second lung tumors following a prior pneumonectomy.
- To identify prognostic factors influencing survival in this patient cohort.
Main Methods:
- Utilized the Surveillance, Epidemiology, and End Results (SEER) database (1998-2016) for patient data.
- Compared treatment-related mortality using Pearson chi-square test.
- Performed Cox regression analyses for cancer-specific survival (CSS) and overall survival (OS).
Main Results:
- Ninety-nine patients were analyzed; 5-year CSS was 60.8% and OS was 53.7%.
- No significant difference in mortality, CSS, or OS between no lung resection (nLR) and lung resection (LR) groups.
- Sublobar resection (SLR) showed improved CSS and OS compared to lobectomy within the LR group.
Conclusions:
- Sublobar resection (SLR) or non-surgical management are reasonable options for resectable postpneumonectomy SLT.
- These approaches achieve long-term survival with acceptable treatment-related mortality.
- Further research may refine treatment strategies for this challenging patient group.
