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Is microRNA 1910-3p (miR-1910-3p) a really distinctive marker for psoriasis?
Melek Karabacak1, İjlal Erturan1, Kuyaş Hekimler Öztürk2
1Department of Dermatology, Faculty of Medicine, Süleyman Demirel University, Isparta, Turkey
Background/Aim:
Although the cause of immune activation in the pathogenesis of psoriasis is still unclear, miRs are thought to have an effect on psoriasis. This work aimed to evaluate the role of miRs (miR-4649-3p, miR-6867-5p, miR-4296, miR-210, and miR-1910-3p) that target the FOXP3 mRNA and IL-17A mRNA in psoriasis.
Materials And Methods:
Forty-four psoriasis patients and 44 healthy controls were included in the study. Quantitative real-time PCR (qRT-PCR) was used for the measurement of miRs. Serum IL-17A levels were determined by an enzyme-linked immunosorbent assay (ELISA) method.
Results:
Plasma miR-1910-3p levels were significantly lower in the patient group than the controls (P = 0.000, fc: 0.10). ROC analysis showed that plasma miR-1910-3p levels could significantly differentiate psoriasis patients from healthy controls [AUC = 0.912 (0.848– 0.975), P = 0.000]. The plasma miR-4649-3p level was significantly higher in the psoriasis group compared to the controls (P = 0.000, fc: 2.99).
Conclusion:
Decreased expression of miR-1910-3p increases the risk of developing psoriasis by approximately 50-fold and was able to use for the significant differentiation of psoriatic patients from healthy controls.
Insights
This study found that lower levels of microRNA-1910-3p (miR-1910-3p) are associated with an increased risk of psoriasis. This microRNA can effectively distinguish psoriasis patients from healthy individuals.
Area of Science:
- Dermatology and Immunology
- Molecular Biology
- Biomarker Discovery
Background:
- The exact cause of immune system activation in psoriasis pathogenesis remains unclear.
- MicroRNAs (miRs) are implicated in the development of psoriasis.
- Specific miRs targeting FOXP3 and IL-17A mRNA are investigated for their role.
Purpose of the Study:
- To evaluate the role of specific miRs (miR-4649-3p, miR-6867-5p, miR-4296, miR-210, and miR-1910-3p) in psoriasis.
- To assess the diagnostic potential of these miRs in differentiating psoriasis patients from healthy controls.
Main Methods:
- Quantitative real-time PCR (qRT-PCR) was employed to measure miR levels in 44 psoriasis patients and 44 healthy controls.
- Serum IL-17A levels were quantified using enzyme-linked immunosorbent assay (ELISA).
- Receiver Operating Characteristic (ROC) curve analysis was performed to evaluate diagnostic accuracy.
Main Results:
- Plasma miR-1910-3p levels were significantly lower in psoriasis patients compared to controls (P = 0.000, fold change: 0.10).
- Plasma miR-4649-3p levels were significantly higher in the psoriasis group (P = 0.000, fold change: 2.99).
- ROC analysis demonstrated that miR-1910-3p could significantly differentiate psoriasis patients from healthy controls (AUC = 0.912).
Conclusions:
- Decreased expression of miR-1910-3p is linked to an approximately 50-fold increased risk of developing psoriasis.
- Plasma miR-1910-3p serves as a significant biomarker for differentiating psoriasis patients from healthy individuals.
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