A biocompatible theranostic nanoplatform based on magnetic gadolinium-chelated polycyclodextrin: in vitro and in vivo...

A novel theranostic nanoplatform was prepared based on Fe₃O₄ nanoparticles (NPs) coated with gadolinium ions decorated-polycyclodextrin (PCD) layer (Fe₃O₄@PCD-Gd) and employed for Curcumin (CUR) loading. The dissolution profile of CUR indicated a pH sensitive release manner. Fe₃O₄@PCD-Gd NPs exhibited no significant toxicity against both normal and cancerous cell lines (MCF 10A and 4T1, respectively); while the CUR-free NPs showed more toxicity against 4T1 than MCF 10A cells. In vivo anticancer study revealed appropriate capability of the system in tumor shrinking with no tissue toxicity and adverse effect on body weight. In vivo MR imaging of BALB/c mouse showed both T₁ and T₂ contrast enhancement on the tumor cells. Fe₃O₄@PCD-Gd/CUR NPs showed significant features as a promising multifunctional system having appropriate T₁-T₂ dual contrast enhancement and therapeutic efficacy in cancer theranostics.