Functionalized phosphorylated cellulose microspheres: Design, characterization and ciprofloxacin loading and...

Area of Science:

• Materials Science
• Biomedical Engineering
• Pharmaceutical Sciences

Background:

• Cellulose microspheres (CM) are biocompatible materials with potential in drug delivery.
• Developing effective carriers for antibiotics like ciprofloxacin (CIP) is crucial for combating bacterial infections.

Purpose of the Study:

• To design and characterize functionalized phosphorylated cellulose microspheres (CMP) as a drug delivery system for ciprofloxacin.
• To evaluate the drug loading, release kinetics, and antibacterial efficacy of CMP-CIP formulations.

Main Methods:

• Cellulose microspheres were functionalized with phosphoric acid via esterification to create CMP.
• Ciprofloxacin was loaded onto CMP through hydrogen bonds and electrostatic interactions.
• Drug release kinetics, structural integrity, cytotoxicity, and antibacterial activity were assessed.

Main Results:

• Successfully synthesized CMP and loaded ciprofloxacin (CIP).
• CMP demonstrated sustained release of CIP following first-order kinetics and non-Fickian diffusion.
• CMP exhibited favorable cytotoxicity, supporting its use as a safe drug vehicle.
• CIP-loaded CMP showed significant antibacterial effects against target pathogens.

Conclusions:

• Functionalized phosphorylated cellulose microspheres are a viable and safe carrier for ciprofloxacin delivery.
• The CMP system offers controlled release and potent antibacterial activity, indicating its therapeutic potential.
• This study highlights the utility of engineered cellulose microspheres for advanced antibiotic drug delivery systems.