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Takotsubo Syndrome and COVID-19: Associations and Implications
Rohan M Shah1, Morish Shah2, Sareena Shah3
1Northwestern University, Chicago, Illinois.
Insights
The COVID-19 pandemic has seen a rise in cardiovascular issues, including takotsubo syndrome. This review explores the link between the novel coronavirus and increased takotsubo cardiomyopathy incidence.
Area of Science:
- Cardiology
- Infectious Diseases
- Psychosomatic Medicine
Background:
- Cardiovascular complications have risen during the COVID-19 pandemic.
- Takotsubo syndrome (also known as stress cardiomyopathy) incidence has increased.
- COVID-19 presents systemic challenges impacting patient care and outcomes.
Purpose of the Study:
- To review the association between COVID-19 and takotsubo syndrome.
- To understand the potential mechanisms linking the novel coronavirus and takotsubo cardiomyopathy.
Main Methods:
- A narrative review of primary studies and case reports was conducted.
- Literature was analyzed to identify trends and proposed mechanisms.
Main Results:
- Increased incidence of takotsubo cardiomyopathy observed in both general and COVID-19 populations.
- Potential mechanisms include psychological distress, cytokine storm, sympathetic overactivity, and microvascular dysfunction.
- Natural disasters are also linked to increased takotsubo syndrome incidence.
Conclusions:
- COVID-19 should be treated as a systemic condition due to its broad impact.
- The rise in takotsubo syndrome is a significant consequence of the COVID-19 pandemic.
- Further research into the cardiovascular effects of COVID-19 is warranted.
Abstract:
Incidence of cardiovascular complications has increased during the COVID-19 (Coronavirus disease 2019) pandemic, both population-wide and in patients diagnosed with the disease. This increase has presented complications in patient care, leading to increased hospitalizations, adverse outcomes, and medical costs. A condition of interest is takotsubo syndrome, which may be associated with the novel coronavirus. To understand this connection, a narrative review was performed by analyzing primary studies and case reports available. The findings showed increased incidence of takotsubo cardiomyopathy in both the general population and COVID-19 patients. Proposed mechanisms for the linkage include generalized increases in psychological distress, the cytokine storm, increased sympathetic responses in COVID-19 patients, and microvascular dysfunction. Moreover, natural disasters are noted as likely being associated with increases of takotsubo syndrome. As the pandemic continues, treating COVID-19 as a systemic condition is imperative, with the increase in takotsubo syndrome marking a significant impact of the novel coronavirus.
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