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Neonatal Murine Cochlear Explant Technique as an In Vitro Screening Tool in Hearing Research

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Hearing screening in neonates with hyperbilirubinemia.

Zahraa Muhammed Ezzeldin¹, Eman Sharaf¹, Hussein Sherif Hamdy²

¹NICU, Pediatric Department, Abou-Reesh Hospital, Cairo University, Egypt.

International Journal of Pediatric Otorhinolaryngology

|December 28, 2020

Summary

Neonatal hyperbilirubinemia is linked to abnormal hearing screening results, particularly auditory neuropathy spectrum disorder. Early detection using auditory brainstem response (ABR) and otoacoustic emissions (OAE) tests is crucial for at-risk infants.

Keywords:

Auditory brainstem response Hyperbilirubinemia Otoacoustic emissions Screening

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Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

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Published on: August 25, 2014

Area of Science:

Neonatal Medicine
Audiology
Neuroscience

Background:

Neonatal hyperbilirubinemia poses risks to auditory pathways and the central nervous system.
Potential sequelae include hearing loss and encephalopathy.
Auditory damage manifests as auditory neuropathy spectrum disorder, affecting the brainstem and cranial nerve VIII.

Purpose of the Study:

To investigate the association between neonatal hyperbilirubinemia and hearing loss.
To establish hyperbilirubinemia as a risk factor for neonatal hearing impairment in infants born at ABOU-EL-REISH hospital.

Main Methods:

A cohort of 60 neonates was divided into two groups: 30 with hyperbilirubinemia and 30 without.
Auditory Brainstem Response (ABR) and Otoacoustic Emissions (OAE) tests were conducted.
Diagnostic accuracy of total serum bilirubin (TSB) levels for hearing screening was evaluated.

Main Results:

A significant difference in ABR results was observed between neonates with and without hyperbilirubinemia (P=0.001).
OAE results showed a statistical difference in the left ear (P=0.028) and a trend in the right ear (P=0.103).
A total serum bilirubin level of 21 mg/dl was identified as a significant cut-off for abnormal ABR results (P=0.008-0.009).

Conclusions:

A significant association exists between elevated bilirubin levels and abnormal neonatal hearing screening.
Combined screening with OAE and ABR tests is recommended for early detection.
Hyperbilirubinemia is a critical risk factor for neonatal hearing impairment.