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Long-term outcome of pemetrexed maintenance for advanced nonsquamous non-small-cell lung cancer: a real-world
Fabrizio Nelli1, Maria Agnese Fabbri2, Luca Moscetti2
1Department of Medical Oncology, Central Hospital of Belcolle, Viterbo, Italy - Outcome Research Network for Evaluation of Treatment Results in Oncology.
Introduction:
Pemetrexed maintenance significantly improved progression-free survival (PFS) and overall survival (OS) in advanced nonsquamous non-small-cell lung cancer (NSCLC) patients not progressing after induction chemotherapy.
Objectives:
This study is aimed at examine the association of various clinical factor and survival in a real-world cohort analysis.
Materials And Methods:
One hundred ninety-four patients were included and classified as "PM" cohort ("Pemetrexed Maintenance", including patients given with pemetrexed maintenance after induction chemotherapy, n=112), and "noPM" cohort ("no Pemetrexed Maintenance" including those discontinuing pemetrexed, n=82).
Results:
The median PFS was 8.8 and 5.4 months in the PM and noPM cohorts, respectively (p=0.001). The median OS was 19.6 months in the "PM" cohort and 13.2 months in the "noPM" cohort (p<0.02). In the multivariate analysis, ECOG Performance Status (PS) 0 and maintenance therapy were independently associated with improved PFS and OS. A longer median PFS was reported in patients given ≥5 cycles of pemetrexed maintenance (p<0.01).
Discussion:
These results further confirm the survival benefit of pemetrexed maintenance in a real-word population. All eligible advanced NSCLC patients should be strongly considered for at least 5 of pemetrexed maintenance.
