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Linearization of two ligand-one binding site scatchard plot and the "IC50" competitive inhibition plot: application
1Department of Neuroscience, University of Florida College of Medicine, Gainesville 32610.
Life Sciences
|January 1, 1988
Abstract:
A simple procedure for linearizing the curved, two ligand-one binding site Scatchard plot resulting from the presence of a constant concentration of competitive inhibitor is proposed; the same procedure may also be applied to the analysis of data derived from the "IC50" competitive inhibition experimental design. Furthermore, a useful generalization of the Cheng-Prusoff correction is presented.