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Updated: Nov 24, 2025

Isolation and Characterization of Neutrophils with Anti-Tumor Properties
Published on: June 19, 2015
Neutrophils as Orchestrators in Tumor Development and Metastasis Formation
Lydia Kalafati1,2, Ioannis Mitroulis2,3, Panayotis Verginis4,5
1Institute for Clinical Chemistry and Laboratory Medicine, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
Abstract:
Several lines of clinical and experimental evidence suggest that immune cell plasticity is a central player in tumorigenesis, tumor progression, and metastasis formation. Neutrophils are able to promote or inhibit tumor growth. Through their interaction with tumor cells or their crosstalk with other immune cell subsets in the tumor microenvironment, they modulate tumor cell survival. Here, we summarize current knowledge with regards to the mechanisms that underlie neutrophil-mediated effects on tumor establishment and metastasis development. We also discuss the tumor-mediated effects on granulopoiesis and neutrophil precursors in the bone marrow and the involvement of neutrophils in anti-tumor therapeutic modalities.
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