Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Mechanism of Angiogenesis

Mechanism of Angiogenesis

Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A digital ELISA for multiplexed detection of allergen-specific IgE against Der p 1, Der p 2, and Der p 23.

Bioengineering & translational medicine·2025

Same author

The theory, technology, and application of terahertz metamaterial biosensors: A review.

Fundamental research·2025

Same author

Membraneless organelles in health and disease: exploring the molecular basis, physiological roles and pathological implications.

Signal transduction and targeted therapy·2024

Same author

ELM2-SANT Domain-Containing Scaffolding Protein 1 Regulates Differentiation and Maturation of Cardiomyocytes Derived From Human-Induced Pluripotent Stem Cells.

Journal of the American Heart Association·2024

Same author

Whole-exome sequencing reveals a novel frameshift mutation in a consanguineous family with a hereditary coagulation factor XII deficiency.

Clinical biochemistry·2023

Same author

Ribosome biogenesis in disease: new players and therapeutic targets.

Signal transduction and targeted therapy·2023

Same journal

Diosmin-Capped Silver Nanoparticles Promote Osteogenic Differentiation of Human Periodontal Ligament Stem Cells: Box-Behnken Optimization and in vitro Evaluation.

International journal of nanomedicine·2026

Same journal

Surfactant-Engineered Niosomal Antibiotic Systems for Biofilm-Associated Infections: Design Principles and Translational Perspectives.

International journal of nanomedicine·2026

Same journal

Application and Future Perspectives of Extracellular Vesicle-Loaded Scaffold in Spinal Cord Injury.

International journal of nanomedicine·2026

Same journal

Identification of Bone Marrow and Peripheral Blood Plasma Extracellular Vesicle Protein Biomarker Signatures for Multiple Myeloma Diagnosis and Staging.

International journal of nanomedicine·2026

Same journal

Se-Fe Hydrogel with Switchable Hyperthermia for Osteosarcoma Therapy.

International journal of nanomedicine·2026

Same journal

A Brain-Targeted Organophosphorus Hydrolase Fusion Protein Mediated by Angiopep-2 Neutralizes Central Organophosphates and Alleviates Neurotoxicity.

International journal of nanomedicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 24, 2025

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

Self-Assembling Peptide-Based Hydrogels in Angiogenesis.

Chaoshan Han¹, Zhiwei Zhang², Jiacheng Sun¹

¹Department of Biomedical Engineering, School of Medicine and School of Engineering, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

International Journal of Nanomedicine

|December 28, 2020

Summary

This summary is machine-generated.

Self-assembling peptide hydrogels offer a novel solution for ischemic diseases by improving the delivery and function of growth factors and cell therapies. These biomaterials enhance tissue recovery and angiogenesis, addressing limitations of current treatments.

Keywords:

angiogenesis hydrogel retention self‐assembling peptide survival

More Related Videos

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids

Published on: May 3, 2024

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Related Experiment Videos

Last Updated: Nov 24, 2025

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Author Spotlight: Improving the Production of Self-Assembling Fibers and Peptide Hydrogels for Superior Biocompatibility

Published on: September 6, 2024

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids

Author Spotlight: Optimization of Ultrashort Peptide Matrices for Colorectal Cancer Organoids

Published on: May 3, 2024

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Area of Science:

Biomaterials Science
Regenerative Medicine
Cardiovascular Research

Background:

Ischemic diseases (heart and brain) pose significant health risks.
Current growth factor and cell therapies have limited retention and function in injured tissues.

Purpose of the Study:

To explore self-assembling peptide (SAP)-based hydrogels as a delivery system for promoting angiogenesis and tissue recovery after ischemia.
To summarize SAP classification, composition, structure, and gelation factors.
To review functionalized SAPs and their combinatorial therapeutic potential.

Main Methods:

Review of literature on self-assembling peptides (SAPs) and their hydrogel formation.
Analysis of functionalized SAPs for controlled release of therapeutic agents (cells, exosomes, growth factors).
Evaluation of combinatorial therapies using SAP hydrogels for angiogenic processes.

Main Results:

SAP hydrogels mimic the extracellular matrix, enabling encapsulation and controlled release of therapeutic agents.
Functionalized SAPs improve retention and sustained function of cells, exosomes, and growth factors.
Combinatorial therapies with SAP hydrogels show promise for enhanced angiogenesis and tissue repair.
SAP hydrogels offer advantages in immunogenicity and injectability.

Conclusions:

SAP-based hydrogels represent a promising strategy for treating ischemic diseases.
These hydrogels enhance the efficacy of cell, exosome, and growth factor therapies.
Future research should focus on optimizing SAP hydrogel design and clinical translation.