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Cis-regulatory Sequences02:02

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Cis-regulatory sequences are short fragments of non-coding DNA that are present on the same chromosomes as the genes that they regulate. These fragments serve as binding sites for transcriptional regulators, proteins that are responsible for controlling gene transcription and differential gene expression across cell types in eukaryotes. Cis-regulatory sequences can be close to the gene of interest or thousands of bases away in the DNA sequence; however, those sequences that are further away are...
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The Photomorphogenic Central Repressor COP1: Conservation and Functional Diversification during Evolution.

Xue Han1,2, Xi Huang3, Xing Wang Deng1,2

  • 1State Key Laboratory of Protein and Plant Gene Research, School of Advanced Agricultural Sciences, Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China.

Plant Communications
|December 28, 2020
PubMed
Summary
This summary is machine-generated.

Constitutive Photomorphogenic 1 (COP1) is a key repressor of plant photomorphogenesis. This review details COP1

Keywords:
COP1E3 ubiquitin ligaseevolutiongravitropismlight protectionphotomorphogenesis

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Area of Science:

  • Plant molecular biology
  • Evolutionary biology
  • Biochemistry

Background:

  • Plants utilize intricate mechanisms to acclimate to sunlight, involving photoreceptors and signaling networks.
  • Constitutive Photomorphogenic 1 (COP1) is a central repressor of photomorphogenesis in higher plants, functioning as a RING E3 ubiquitin ligase.
  • COP1 targets light-signaling regulators for degradation within large protein complexes, and its mammalian counterpart influences tumorigenesis and metabolism.

Purpose of the Study:

  • To review the current understanding of COP1.
  • To focus on the conservation and functional diversification of COP1 and its signaling partners across different taxonomic clades.
  • To illustrate the evolutionary history of COP1 using data from whole-genome sequencing and functional studies in lower green plants.

Main Methods:

  • Review of existing literature on COP1.
  • Analysis of whole-genome sequencing data.
  • Examination of functional studies in various plant species.

Main Results:

  • COP1 acts as a crucial regulator in light signaling pathways across diverse plant species.
  • Significant conservation of COP1 function exists, alongside functional diversification in different plant lineages.
  • The evolutionary history of COP1 provides insights into plant adaptation to light environments.

Conclusions:

  • COP1 is a highly conserved and functionally diversified protein essential for plant photomorphogenesis.
  • Understanding COP1's evolution aids in comprehending plant responses to light.
  • COP1 signaling partners also exhibit evolutionary conservation and diversification, impacting plant development.