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Genotype-guided dietary supplementation in precision nutrition
Kalliopi K Gkouskou1,2, Maria G Grammatikopoulou3, Ioannis Vlastos1
1Department of Biology, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
Nutrition Reviews
|December 28, 2020
Summary
Personalized nutrition is advancing, with genetic insights guiding oral nutrient supplementation (ONS). Tailoring supplements to individual genotypes optimizes micronutrient status and health benefits, reducing risks and costs.
Area of Science:
- Nutritional Genomics
- Precision Medicine
- Micronutrient Metabolism
Background:
- Global challenge in achieving adequate micronutrient status.
- Widespread use of oral nutrient supplementation (ONS) to address dietary gaps.
- Emerging role of nutrigenetics in personalized nutrition strategies.
Purpose of the Study:
- To review evidence linking genetic variants to responses to common dietary supplements.
- To highlight the importance of genotype-matched ONS in precision nutrition.
- To inform healthcare professionals on optimizing supplement prescriptions.
Main Methods:
- Systematic review of published literature.
- Analysis of studies on genetic variations and micronutrient supplement responses.
- Focus on popular dietary supplements and their efficacy based on genotype.
Main Results:
- Genetic makeup influences individual responses to micronutrient supplementation.
- Specific genetic variants correlate with varying efficacy of dietary supplements.
- Evidence supports tailoring ONS based on genetic profiles for improved outcomes.
Conclusions:
- Genotype-specific supplementation enhances health benefits and micronutrient balance.
- Precision nutrition through ONS can minimize adverse events and healthcare costs.
- Integrating genetic data into ONS prescription is crucial for optimal health outcomes.
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