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Updated: Nov 24, 2025

Assessment of Kidney Function in Mouse Models of Glomerular Disease
Published on: June 30, 2018
Serum albumin measurement in nephrology: room for improvement
Marith van Schrojenstein Lantman1,2,3, Anne-Els van de Logt4, Marc Thelen1,2,3
1Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands.
Abstract:
Serum albumin is a widely used biomarker in clinical nephrology. Serum albumin cut-off values are used to define disease, to predict outcome and to guide patient care. The available commercial assays to measure serum albumin rely on different analytical principles, all with their own (analytical) specifications. This article provides an overview of the different clinical applications of serum albumin measurements in nephrology, the (dis)advantages of the available assays and the estimates of the effects of the measurement uncertainty between different assays in clinical decision making. This article concludes that harmonization of serum albumin assay results is needed.
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