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Population Pharmacodynamic Modeling Using the Sigmoid Emax Model: Influence of Inter-individual Variability on the

Johannes H Proost1,2, Douglas J Eleveld3, Michel M R F Struys3,4

  • 1Department of Anesthesiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ, Groningen, the Netherlands. j.h.proost@umcg.nl.

The AAPS Journal
|December 28, 2020
PubMed
Summary

The steepness of drug concentration-effect relationships is influenced by inter-individual variability (IIV). Population modeling may underestimate this steepness, impacting drug effect predictions.

Keywords:
inter-individual variabilitypharmacokinetic-pharmacodynamic modelingsigmoid Emax modelsimulation

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