Effect of prostate volume on f/tPSA value: A cross-sectional study.

Area of Science:

• Urology
• Andrology
• Medical Diagnostics

Background:

• Prostate-specific antigen (PSA) and prostate volume (PV) are key indicators in prostate health.
• The ratio of free to total PSA (f/tPSA) is crucial for differentiating benign prostatic conditions from prostate cancer.
• Understanding the interplay between PV and f/tPSA can enhance diagnostic accuracy for prostate diseases.

Purpose of the Study:

• To investigate the association between prostate volume (PV) and the free to total PSA (f/tPSA) ratio in men with lower urinary tract symptoms (LUTS).
• To determine if PV influences f/tPSA levels and its potential impact on diagnostic value.

Main Methods:

• A cohort of 342 men with LUTS underwent urinary tract ultrasonography and PSA testing.
• Serum glucose, lipids, and blood pressure were also measured.
• Univariate and multivariate analyses were employed to assess the relationship between PV and f/tPSA.

Main Results:

• A significant positive correlation was observed between prostate volume and f/tPSA when PSA levels ranged from 4 to 10 ng/ml (HR: 0.0012; 95% CI: 0.0009-0.0248).
• Multivariate analysis confirmed that increasing PV was associated with a significant increase in f/tPSA (HR: 0.0011; 95% CI: 0.0007-0.0015; p ≤ 0.0001).
• No significant correlation between PV and f/tPSA was found when PSA levels exceeded 10 ng/ml.

Conclusions:

• Prostate volume demonstrably affects serum f/tPSA levels.
• The positive correlation between PV and f/tPSA is evident within the 4-10 ng/ml PSA range.
• These findings suggest that PV should be considered in the interpretation of f/tPSA values for improved prostate disease diagnosis.