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Mindfulness-based cognitive therapy in functional dyspepsia: A pilot randomized trial.

Kevin Kim-Jun Teh1, Yi-Kang Ng2, Kinjal Doshi3

  • 1Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore.

Journal of Gastroenterology and Hepatology
|December 29, 2020
PubMed
Summary

Mindfulness-based cognitive therapy (MBCT) shows promise for functional dyspepsia (FD) management. This pilot study suggests MBCT is feasible and potentially effective, warranting further investigation in a larger randomized controlled trial (RCT).

Keywords:
cognitive behavioral therapydyspepsiamindfulnesspsychological intervention

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Area of Science:

  • Gastroenterology
  • Psychiatry
  • Mindfulness-based interventions

Background:

  • Functional dyspepsia (FD) frequently co-occurs with anxiety and depression.
  • Mindfulness-based cognitive therapy (MBCT) integrates cognitive behavioral therapy and mindfulness principles.
  • MBCT has demonstrated efficacy in functional gastrointestinal disorders, but its role in FD requires further study.

Purpose of the Study:

  • To assess the feasibility and efficacy of MBCT for managing functional dyspepsia.
  • To evaluate patient recruitment, intervention acceptability, and adherence in a pilot randomized trial.

Main Methods:

  • A mixed-method, single-center pilot randomized trial involving 28 patients with FD.
  • Patients were randomized to an 8-week MBCT program or treatment-as-usual (TAU).
  • Feasibility was assessed through recruitment, randomization, intervention procedures, and quantitative measures; efficacy was evaluated using symptom questionnaires.

Main Results:

  • The MBCT program demonstrated good feasibility, with 12 out of 15 patients completing the intervention.
  • A trend towards improved FD symptoms was observed (90% MBCT vs. 45% TAU, P=0.063).
  • MBCT significantly improved the Nepean Dyspepsia Index (P=0.018) and showed a trend in reducing depression, anxiety, and stress scores.

Conclusions:

  • Mindfulness-based cognitive therapy (MBCT) appears to be a feasible and potentially efficacious intervention for functional dyspepsia.
  • A larger randomized controlled trial (RCT) with approximately 50 patients is recommended to confirm these findings.