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Shaping Block Copolymer Microparticles by pH-Responsive Core-Cross-Linked Polymeric Nanoparticles.

Mengmeng Zhang1, Zaiyan Hou1, Huiying Wang1

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Langmuir : the ACS Journal of Surfaces and Colloids
|December 29, 2020
PubMed
Summary

Researchers developed a simple method to control the morphology of polystyrene-block-poly(dimethylsiloxane) (PS-b-PDMS) microparticles. By adding pH-responsive core-cross-linked polymeric nanoparticles (CNPs), the microparticles transform shape with changing pH.

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Area of Science:

  • Polymer Science
  • Materials Science
  • Nanotechnology

Background:

  • Block copolymer (BCP) microparticles offer tunable properties for advanced applications.
  • Controlling the morphology of BCP microparticles is crucial for optimizing their performance.
  • Current methods for morphology control often lack simplicity or broad applicability.

Purpose of the Study:

  • To develop a facile method for controlling the morphology of pH-inert PS-b-PDMS microparticles.
  • To investigate the mechanism of pH-induced shape transformation.
  • To demonstrate the potential of this method for other non-pH-responsive BCPs.

Main Methods:

  • Synthesis of core-cross-linked polymeric nanoparticles (CNPs) from PS-b-P4VP.
  • Utilizing CNPs as cosurfactants in the formation of PS-b-PDMS microparticles.
  • Investigating morphology changes by varying pH, CNP concentration, and surfactant properties.

Main Results:

  • PS-b-PDMS microparticles exhibited pH-sensitive morphology changes when co-assembled with CNPs.
  • Microparticles transformed from elongated Janus pupa-like to onion-like structures upon decreasing pH.
  • The deformation mechanism was elucidated through systematic variation of experimental parameters.

Conclusions:

  • A simple and effective strategy was established to induce morphology transformation in pH-inert BCP microparticles.
  • The use of pH-responsive CNPs provides a versatile tool for tuning microparticle shape.
  • This approach holds promise for designing functional microparticles for diverse applications.