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Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms
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Quantitative Measurement of γ-Secretase-mediated Amyloid Precursor Protein and Notch Cleavage in Cell-based Luciferase Reporter Assay Platforms

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Structural basis of γ-secretase inhibition and modulation by small molecule drugs

Guanghui Yang1, Rui Zhou2, Xuefei Guo2

  • 1Beijing Advanced Innovation Center for Structural Biology and Research Center for Biological Structure, Tsinghua-Peking Joint Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China; State Key Laboratory for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China.

Cell
|December 29, 2020
PubMed

Keywords:
cryo-EMdruginhibitormodulatorstructureγ-secretase

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