Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A pump-free microfluidic device for integrated multi-functional testing of tumor spheroids.

APL bioengineering·2026
Same author

Colloid-patterned surfaces distinguish malignant mechanophenotypes.

Materials today. Bio·2026
Same author

Toward FGF2 reduction in cultured meat media: polyphenol salts enhance growth and differentiation of bESC aggregates.

Frontiers in nutrition·2025
Same author

Development and Characterization of a High-CBD Cannabis Extract Nanoemulsion for Oral Mucosal Delivery.

International journal of molecular sciences·2025
Same author

Structural Control for Tunable Hyperthermia-Induced Cellular Responses Using 3D-Printed Platforms.

ACS biomaterials science & engineering·2025
Same author

Immunomodulatory Effects of a High-CBD Cannabis Extract: A Comparative Analysis with Conventional Therapies for Oral Lichen Planus and Graft-Versus-Host Disease.

International journal of molecular sciences·2025

Related Experiment Video

Updated: Nov 23, 2025

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays
11:33

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays

Published on: March 9, 2017

16.1K

3D Printed Microfluidic Devices for Drug Release Assays.

Benzion Amoyav1, Yoel Goldstein1, Eliana Steinberg1

  • 1The Institute for Drug Research, School of Pharmacy, The Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.

Pharmaceutics
|December 30, 2020
PubMed
Summary

This study introduces a novel one-step 3D printing method for microfluidic drug dissolution assays. This 3D printed microfluidic chip offers a cost-effective and efficient alternative to traditional fabrication methods.

Keywords:
3d printingchip manufacturingdissolution testmicrofabricationmicrofluidicsmicrospheresporous

More Related Videos

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

21.5K
The Submerged Printing of Cells onto a Modified Surface Using a Continuous Flow Microspotter
08:29

The Submerged Printing of Cells onto a Modified Surface Using a Continuous Flow Microspotter

Published on: April 22, 2014

8.9K

Related Experiment Videos

Last Updated: Nov 23, 2025

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays
11:33

Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays

Published on: March 9, 2017

16.1K
Microfluidic Chips Controlled with Elastomeric Microvalve Arrays
18:11

Microfluidic Chips Controlled with Elastomeric Microvalve Arrays

Published on: October 1, 2007

21.5K
The Submerged Printing of Cells onto a Modified Surface Using a Continuous Flow Microspotter
08:29

The Submerged Printing of Cells onto a Modified Surface Using a Continuous Flow Microspotter

Published on: April 22, 2014

8.9K

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Analytical Chemistry

Background:

  • Microfluidics offers significant potential in drug delivery and biomedical research.
  • Traditional microfluidic chip fabrication often involves complex, multi-step processes like lithography.
  • There is a need for more accessible and efficient microfluidic fabrication methods.

Purpose of the Study:

  • To develop a one-step fabrication process for microfluidic chips using 3D printing technology.
  • To create a microfluidic platform for drug dissolution assays.
  • To compare microfluidic and batch methods for microsphere fabrication.

Main Methods:

  • A one-step 3D printing technique was employed to fabricate microfluidic chips.
  • Doxorubicin-loaded porous and non-porous microspheres (250µm) were produced using a microfluidic or batch method.
  • Drug release profiles were analyzed using two dissolution devices with different barrier structures (V-shape and basket).
  • Cytotoxicity tests were performed to assess the biocompatibility of the 3D printed resin.

Main Results:

  • Microfluidically fabricated microspheres showed higher drug encapsulation efficiency and content compared to batch methods.
  • Drug release profiles varied depending on the dissolution device's barrier structure.
  • The 3D printed resin demonstrated biocompatibility through cytotoxicity testing.
  • The microfluidic chip exhibited durability and stability, allowing for multiple uses.

Conclusions:

  • Combining microfluidics and 3D printing provides an efficient, cost-effective platform for microsphere production and drug dissolution assays.
  • This approach reduces fabrication time and costs, offering an alternative to traditional polydimethylsiloxane-based microfluidic chip fabrication.
  • The developed microfluidic chip is suitable for various biomedical research applications.