Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anatomy of the Intestines01:23

Anatomy of the Intestines

85.7K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
85.7K
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.0K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.0K
Aging01:26

Aging

441
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
441
Mitochondria01:37

Mitochondria

18.0K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
18.0K
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

98
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
98
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

100
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
100

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Differences in the content of five bioactive components in <i>Dendropanax dentiger</i> (Harms) Merr. from different production areas and their correlation with geographic distribution and climatic factors.

Frontiers in pharmacology·2026
Same author

Impact of carbapenem-resistant <i>Klebsiella pneumoniae</i> infection on gut microbiota and host immunity: a case-control study.

Microbiology spectrum·2025
Same author

Gut microbiota dysbiosis and systemic immune dysfunction in critical ill patients with multidrug-resistant bacterial colonization and infection.

Journal of translational medicine·2025
Same author

Interplay of social integration, well-being, and fairness in older migrant workers: a four -year longitudinal analysis.

Population health metrics·2025
Same author

Huoxiang-Shihu herbal formula attenuates alcoholic-induced gastric injury by regulating the HIF-1α/VEGF pathway and inhibiting oxidative stress.

Journal of ethnopharmacology·2025
Same author

Dynamic changes in network structure of depressive symptoms: a two-year naturalistic follow-up study.

BMC psychiatry·2025

Related Experiment Video

Updated: Nov 23, 2025

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health
11:40

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

Published on: April 28, 2022

3.0K

Gut microbiota and aging.

Zongxin Ling1, Xia Liu2, Yiwen Cheng1

  • 1Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Critical Reviews in Food Science and Nutrition
|December 30, 2020
PubMed
Summary

The gut microbiota significantly impacts aging. Understanding microbial changes and targeting the gut microbiome offers promising strategies for healthy aging and combating age-related diseases.

Keywords:
Agingbacterial diversityfecal microbiota transplantationgut microbiotalifespansuccession

More Related Videos

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

30.7K
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

14.5K

Related Experiment Videos

Last Updated: Nov 23, 2025

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health
11:40

High-Throughput Screening of Microbial Isolates with Impact on Caenorhabditis elegans Health

Published on: April 28, 2022

3.0K
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

30.7K
Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota
06:23

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

14.5K

Area of Science:

  • Microbiology
  • Gerontology
  • Immunology

Background:

  • Aging involves tissue and organ functional decline, increasing disease risk.
  • Genetics research has yielded limited insights into aging mechanisms.
  • The gut microbiota's role in aging is increasingly recognized.

Purpose of the Study:

  • To review the gut microbiota's physiological succession throughout life.
  • To explore the gut microbiota's mechanisms in healthy aging.
  • To discuss microbiota alterations in aging diseases and anti-aging strategies.

Main Methods:

  • Literature review of recent findings on gut microbiota and aging.
  • Analysis of microbial succession across the life-cycle.
  • Examination of microbiota's role in immune responses (immunosenescence and inflammaging).

Main Results:

  • Age-related microbial dysbiosis influences immune system changes.
  • Gut microbiota alterations are linked to various age-associated diseases.
  • The gut microbiota presents a modifiable target for anti-aging interventions.

Conclusions:

  • The gut microbiota plays a crucial role in the aging process.
  • Targeting the gut microbiome offers potential for promoting healthy aging.
  • Further research into microbiota-targeted strategies is warranted for age-related health challenges.