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Long sleep duration and cardiovascular disease: Associations with arterial stiffness and blood pressure variability

Hideaki Matsubayashi1, Michiaki Nagai1, Keigo Dote1

  • 1Department of Cardiology, Hiroshima City Asa Hospital, Hiroshima, Japan.

Journal of Clinical Hypertension (Greenwich, Conn.)
|December 30, 2020
PubMed

Insights

Long sleep duration increases cardiovascular disease (CVD) mortality risk, potentially through arterial stiffness and blood pressure variability (BPV). Further research is needed to clarify these mechanisms and their impact on heart health.

Area of Science:

  • Cardiology
  • Sleep Medicine
  • Public Health

Background:

  • Both short and long sleep durations are recognized risk factors for cardiovascular disease (CVD).
  • Recent meta-analyses highlight a significant association between long sleep duration and increased CVD mortality.
  • The precise mechanisms linking prolonged sleep to CVD remain incompletely understood.

Purpose of the Study:

  • To review the pathophysiology connecting long sleep duration, arterial stiffness, and blood pressure variability (BPV).
  • To explore the effects of these factors on cardiovascular disease.
  • To synthesize current understanding of the relationship between long sleep, arterial stiffness, BPV, and CVD.

Main Methods:

  • Literature review focusing on studies examining long sleep duration, arterial stiffness, BPV, and CVD.
  • Analysis of existing meta-analyses and epidemiological data.
  • Synthesis of pathophysiological insights from relevant research.

Main Results:

  • Long sleep duration is associated with increased arterial stiffness.
  • Elevated blood pressure variability (BPV) is linked to prolonged sleep.
  • These physiological changes may mediate the relationship between long sleep and CVD mortality.

Conclusions:

  • Long sleep duration represents a significant risk factor for cardiovascular disease mortality.
  • Arterial stiffness and blood pressure variability are potential pathophysiological pathways.
  • Further investigation is warranted to fully elucidate the mechanisms and clinical implications.

Keywords:
arterial stiffnessblood pressure variabilitycardiovascular diseasesleep duration

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