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Related Concept Videos

Aging01:26

Aging

441
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
441
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.0K
Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
100
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

87
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
87
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

98
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
98
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

108
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
108

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Updated: Nov 23, 2025

A Phenotyping Regimen for Genetically Modified Mice Used to Study Genes Implicated in Human Diseases of Aging
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ARDD 2020: from aging mechanisms to interventions.

Garik V Mkrtchyan1, Kotb Abdelmohsen2, Pénélope Andreux3

  • 1Center for Healthy Aging, Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.

Aging
|December 30, 2020
PubMed
Summary
This summary is machine-generated.

Aging is a druggable target, with new technologies and industry focus accelerating discoveries for age-related diseases. The 7th Annual Aging Research and Drug Discovery meeting highlighted advancements in aging research and interventions.

Keywords:
agingartificial intelligencedrug discoveryinterventions

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Area of Science:

  • Gerontology
  • Biotechnology
  • Pharmacology

Background:

  • Aging is increasingly recognized as a modifiable biological process.
  • Significant investment and technological advancements are driving aging research.
  • Academia and industry are collaborating to develop interventions for age-related diseases.

Purpose of the Study:

  • To summarize key findings and discussions from the 7th Annual Aging Research and Drug Discovery (ARDD) meeting.
  • To highlight advancements in methodologies, basic aging mechanisms, and interventional strategies.
  • To discuss the societal and economic impact of aging research.

Main Methods:

  • Review of presentations from the 7th ARDD meeting (September 1-4, 2020).
  • Synthesis of information on new aging research technologies, longevity mechanisms, and therapeutic strategies.
  • Inclusion of discussions on the broader implications of aging research.

Main Results:

  • The meeting showcased novel technologies like artificial intelligence and advanced screening for aging research.
  • Key topics included basic longevity mechanisms and cutting-edge interventional strategies.
  • Discussions emphasized the growing economic and societal impact of targeting aging.

Conclusions:

  • Aging research is a rapidly advancing field with significant potential for treating age-related diseases.
  • Technological innovation and industry involvement are crucial drivers of progress.
  • The 7th ARDD meeting underscored the collaborative and impactful nature of current aging research efforts.