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Long-term application of hydroxychloroquine could not prevent the infection of COVID-19

Yin Zhu1, Yongping Chen2, Yuewen Gong3

  • 1Department of Infectious Diseases and Liver Diseases, Ningbo Medical Center Lihuili Hospital, Affiliated Hospital of Ningbo University, China. 923453707@qq.com.

Journal of Infection in Developing Countries
|December 30, 2020
PubMed

Insights

Long-term use of hydroxychloroquine (HCQ) did not prevent a patient from contracting COVID-19. Further research is needed to determine if HCQ helps alleviate COVID-19 symptoms or reduces hospital stays.

Area of Science:

  • Infectious Diseases
  • Rheumatology
  • Pharmacology

Background:

  • The COVID-19 pandemic highlights the urgent need for effective treatments, with hydroxychloroquine (HCQ) being a subject of significant debate regarding its efficacy.
  • This report details a case of a patient with rheumatoid arthritis on long-term HCQ treatment who contracted COVID-19.

Observation:

  • A 63-year-old female rheumatoid arthritis patient on long-term HCQ (200 mg/day) contracted COVID-19.
  • The patient presented with pneumonia, lymphopenia, elevated hs-CRP, and IL-6.
  • She received standard COVID-19 treatment alongside HCQ.

Findings:

  • Long-term hydroxychloroquine use did not confer immunity against SARS-CoV-2 infection.
  • The patient recovered from COVID-19, developing antibodies post-treatment.
  • The study did not definitively prove or disprove HCQ's efficacy in symptom management or hospital stay duration.

Implications:

  • This case suggests that HCQ may not prevent COVID-19, even with prolonged use.
  • Further clinical trials are necessary to evaluate HCQ's therapeutic potential in COVID-19 patients.
  • Investigating HCQ's interaction with COVID-19 in patients with underlying autoimmune diseases is warranted.
Abstract

Keywords:
COVID-19case reporthydroxychloroquinepreventiontreatment

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