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Coiled coil-based therapeutics and drug delivery systems
Johanna Utterström1, Sajjad Naeimipour1, Robert Selegård1
1Laboratory of Molecular Materials, Division of Biophysics and Bioengineering, Department of Physics, Chemistry and Biology, Linköping University, 581 83 Linköping, Sweden.
Advanced Drug Delivery Reviews
|December 30, 2020
Summary
Coiled coils, protein structures that assemble α-helices, offer versatile tools for creating advanced drug delivery systems. These protein motifs enable precise control over drug release, targeting, and uptake for novel therapeutics.
Area of Science:
- Protein structural biology
- Biomolecular engineering
- Nanotechnology
Background:
- Coiled coils are protein motifs formed by two or more α-helices in a superhelical arrangement.
- Their sequence-to-structure relationship is well-understood, enabling predictable design.
- Natural and designed coiled coils serve as building blocks for complex molecular architectures and materials.
Purpose of the Study:
- To review strategies for utilizing coiled coils in the design of novel therapeutics.
- To discuss the application of coiled coils in advanced drug delivery systems.
- To explore coiled coils for enhancing drug targeting, uptake, and controlled release.
Main Methods:
- Review of existing literature on coiled coil applications in medicine and materials science.
- Analysis of design principles for tuning coiled coil affinities and oligomerization.
- Exploration of coiled coil-based systems for drug carriers, vaccines, and triggered release mechanisms.
Main Results:
- Coiled coils provide a modular and dynamic platform for designing responsive molecular assemblies.
- Applications include the development of drug carriers, vaccines, and targeted delivery vehicles.
- Coiled coils enable precise control over drug release kinetics and cellular uptake.
Conclusions:
- Coiled coil-based systems offer innovative strategies for improving the efficacy of existing drugs.
- These protein motifs facilitate the development of novel therapeutic approaches.
- Coiled coils represent a powerful molecular toolbox for advanced nanomedicine and drug development.
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