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Related Concept Videos

Induced Pluripotent Stem Cells01:13

Induced Pluripotent Stem Cells

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Induced Pluripotent Stem Cells01:06

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic...
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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
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EPS and iPS Cells in Disease Research01:21

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Embryonic and induced pluripotent stem cells are excellent models for disease research because of their ability to self-renew and differentiate into most cell types. Somatic cells from a patient are isolated and reprogrammed into induced pluripotent stem cells or iPSCs. These iPSCs are later differentiated into the desired cell type, which mirrors the diseased cell of the patient. In this way, disease models have been created for investigating diseases such as Down syndrome, type I diabetes,...
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Stem Cell Culture01:17

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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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iPS Cell Differentiation01:22

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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Related Experiment Video

Updated: Nov 23, 2025

Intracerebral Transplantation and In Vivo Bioluminescence Tracking of Human Neural Progenitor Cells in the Mouse Brain
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Revisiting Stem Cell-Based Clinical Trials for Ischemic Stroke.

Joy Q He1, Eric S Sussman2, Gary K Steinberg2,3,4

  • 1Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, United States.

Frontiers in Aging Neuroscience
|December 31, 2020
PubMed
Summary
This summary is machine-generated.

Stem cell therapies show promise for stroke recovery, offering potential neurorestoration for chronic stroke patients. This review examines hematopoietic, mesenchymal, and neural stem cell trials for improving function after ischemic stroke.

Keywords:
cell lineagesclinical trialsischemic strokestem cellstransplantation

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Clinical Neurology

Background:

  • Stroke is a primary cause of long-term disability, particularly reduced mobility in older adults.
  • Current treatments for chronic stroke lack proven neurorestorative capabilities.
  • Restoring function in ischemic brain tissue remains a significant challenge.

Purpose of the Study:

  • To review the scientific rationale for stem cell transplantation in treating ischemic stroke.
  • To provide an overview of stem cell-based clinical trials for stroke.
  • To categorize trials based on hematopoietic, mesenchymal, and neural stem cell lineages.

Main Methods:

  • Literature review of published and ongoing clinical trials.
  • Categorization of stem cell therapies by cell lineage (hematopoietic, mesenchymal, neural).
  • Analysis of the scientific basis for using each cell type in stroke recovery.

Main Results:

  • Stem cell transplantation is being explored as a potential restorative therapy for ischemic stroke.
  • Clinical trials are investigating three main stem cell types: hematopoietic, mesenchymal, and neural.
  • Each cell lineage has a distinct scientific rationale for its use in stroke treatment.

Conclusions:

  • Stem cell transplantation offers a promising avenue for neurorestoration in chronic stroke.
  • Understanding the different cell lineages is crucial for advancing stroke therapy.
  • Further research and clinical trials are needed to establish efficacy and optimize treatments.